Acetaminophen Overdose Reveals PAR4 as a Low Expressing but Potent Receptor on the Hepatic Endothelium in Mice Arteriosclerosis, Thrombosis, and Vascular Biology Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Hidden Impact of Acetaminophen Well Rooted PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre Acetaminophen Glutathione Disodium Salt CAS 64889 81 2 (free acid) SCBT Santa Cruz Biotechnology Acetaminophen Depletes Glutathione Essential Formulas